ChemicalBook > CAS DataBase List > Y-27632 DIHYDROCHLORIDE

Y-27632 DIHYDROCHLORIDE

Product Name
Y-27632 DIHYDROCHLORIDE
CAS No.
146986-50-7
Chemical Name
Y-27632 DIHYDROCHLORIDE
Synonyms
Y-27632;ROCK INHIBITOR;Y-276322HCl;Rock inhibitor y-27632;(1R,4R)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide;CS-20;Y-27632/Y27632;Y-27632 (2HCl),98%;Y-27632, free base;Y-27632 dihydrochlor
CBNumber
CB0699488
Molecular Formula
C14H21N3O
Formula Weight
247.34
MOL File
146986-50-7.mol
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Y-27632 DIHYDROCHLORIDE Property

Melting point:
>260°C (dec.)
Boiling point:
462.6±15.0 °C(Predicted)
Density 
1.136±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
H2O: 14 mg/mL
form 
solid
pka
13.53±0.40(Predicted)
color 
white
Stability:
Hygroscopic
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.09228
Product name
InSolution Y-27632, Sterile-Filtered, Cell Culture-Tested - CAS 146986-50-7 - Calbiochem
Packaging
2mg
Price
$378
Updated
2024/03/01
Sigma-Aldrich
Product number
688000
Product name
Y-27632 - CAS 146986-50-7 - Calbiochem
Packaging
1MG
Price
$238
Updated
2023/01/07
Sigma-Aldrich
Product number
688000
Product name
Y-27632 - CAS 146986-50-7 - Calbiochem
Packaging
5MG
Price
$894
Updated
2023/01/07
Sigma-Aldrich
Product number
688000
Product name
Y-27632 - CAS 146986-50-7 - Calbiochem
Packaging
10MG
Price
$1200
Updated
2023/01/07
Sigma-Aldrich
Product number
688000
Product name
Y-27632 - CAS 146986-50-7 - Calbiochem
Packaging
100MG
Price
$2170
Updated
2023/01/07
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Y-27632 DIHYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Y-27632 Dihydrochloride is a salt analog of Y-27632, which is Rho-kinase inhibitor.

Definition

ChEBI: A monocarboxylic acid amide that is trans-[(1R)-1-aminoethyl]cyclohexanecarboxamide in which one of the nitrogens of the aminocarbony group is substituted by a pyridine nucleus. It has been shown to exhibit inhibitory acti ity against Rho-associated protein kinase (ROCK) enzyme.

Biological Activity

Selective inhibitor of the Rho-associated protein kinase p160ROCK. K i values are 0.14, 26, 25 and >250 μ M for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase respectively. Also inhibits the protein kinase C-related protein kinase, PRK2 (IC 50 = 600nM). Smooth muscle relaxant and orally active in vivo . Increases survival rate of human embryonic stem (hES) cells undergoing cryopreservation.

References

[1] ishizaki t1, uehata m, tamechika i, keel j, nonomura k, maekawa m, narumiya s. pharmacological properties of y-27632, a specific inhibitor of rho-associated kinases. mol pharmacol. 2000 may;57(5):976-83.

Y-27632 DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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Y-27632 DIHYDROCHLORIDE Suppliers

China 133 Germany 3 Japan 2 Switzerland 2 United Kingdom 4 United States 26 Global 170
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View Lastest Price from Y-27632 DIHYDROCHLORIDE manufacturers

Career Henan Chemical Co
Product
Y-27632 DIHYDROCHLORIDE 146986-50-7
Price
US $2.00/KG
Min. Order
1g
Purity
98%MIN
Supply Ability
ASK
Release date
2020-01-07

146986-50-7, Y-27632 DIHYDROCHLORIDERelated Search:

Y-27632 (2HCl), 5 mg Y6 Y27632 (hydrochloride) N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Y320 (R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride (R)-(+)-3-Butyn-2-ol (R)-(1-(4-nitrophenyl))ethanol Y-27632 DIHYDROCHLORIDE 1,4-Cyclohexanebis(methylamine)

  • ROCK INHIBITOR
  • (R)-(+)-TRANS-N-(4-PYRIDYL)-4-(1-AMINOETHYL)-CYCLOHEXANECARBOXAMIDE 2HCL
  • (R)-(+)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL)CYCLOHEXANECARBOXAMIDE DIHYDROCHLORIDE
  • (+)-R-TRANS-4-(AMINOETHYL)-N-(4-PYRIDYL)-CYCLOHEXANECARBOXAMIDE 2HCL H2O
  • Y-27632
  • Y-27632 DIHYDROCHLORIDE
  • TRANS-4-[(1R)-1-AMINOETHYL]-N-4-PYRIDINYLCYCLOHEXANECARBOXAMIDE DIHYDROCHLORIDE
  • Y-276322HCl
  • 4-[(1R)-1-Aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide dihydrochloride
  • (1R,4r)-4-((R)-1-aMinoethyl)-N-(pyridin-4-yl)cyclohexanecarboxaMide dihydrochloride
  • CyclohexanecarboxaMide,4-[(1R)-1-aMinoethyl]-N-4-pyridinyl-, trans-
  • Y-27632/Y27632
  • Y-27632, Free Base, >99%
  • (+)-Trans-4-[1(r)-aminoethyl]-n-(4-pyridyl)cyclohexane-1-carboxamide
  • Y-27632 (2HCl),98%
  • 4-[(1R)-1-Aminoethyl]-N-(4-pyridinyl)cyclohexanecarboxamide
  • (1R,4R)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide
  • Y-27632, free base
  • 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-trans-cyclohexanecarboxamide
  • 4-[(1R)-1-Aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide
  • (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexane-1-carboxamide dihydrochloride
  • CS-20
  • 4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexane-1-carboxamide
  • (+)-(R)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide
  • (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4(1H)-ylidene)cyclohexanecarboxamide
  • Y-27632 dihydrochlor
  • Rock inhibitor y-27632
  • trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide
  • 146986-50-7
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Kinase/Phosphatase Biology
  • Rho Kinase (ROCK)
  • Serine/Threonine Kinase Inhibitors
  • Inhibitors
  • Protein Kinase
  • Signalling
  • Inhibitor
  • APIs
  • SiChem